Webb19 jan. 2024 · Arrakis’ approach is to find the gene associated with the disease, then find the sequence on the gene that is functionally relevant, use this to build the RNA with the right structure, perform the screen, and find the molecules that go … Webb9 apr. 2024 · Arrakis Therapeutics has signed a collaboration and licence agreement with Roche to identify RNA-targeted small molecule (rSM) drugs against various in different therapeutic areas. The partners will develop RNA-targeted small molecule drugs for various diseases. Credit: Michał Parzuchowski on Unsplash.
Nabanita De - Associate Directo.. - Arrakis Therapeutics - ZoomInfo
WebbRNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of method... RNA is emerging as a valuable target for the development of novel therapeutic agents. Webb8 apr. 2024 · Now, Arrakis has its first big pharma partner. Roche is paying Arrakis $190 million in cash to begin developing RNA-targeted small-molecule drugs against multiple … shape up us
Arrakis reels in $75 million to drug RNA with small molecules
Webb18 apr. 2024 · Arrakis has determined the structure of Myc messenger RNA, Gilman says, and discovered multiple small molecules that might inhibit the translation of the RNA into protein. Right now, Arrakis is focusing almost entirely on drugging messenger RNA. It has a list of about 50 favorite targets, mostly related to cancer. Webb1 okt. 2024 · Arrakis has since commenced its screening program, and Gilman says that the firm hopes to screen “hundreds of RNAs” this year against “many millions” of molecules, resulting in data points that... SHAPEware is a set of computational tools for researchers to explore and predict the secondary structure and potential ligand binding sites in an RNA using SHAPE (Selective 2′ Hydroxyl Acylation analyzed by Primer Extension) methodologies. SHAPE is the most widely used approach for probing RNA secondary structure and was developed by Kevin ... shape up with mary hart