WebJun 23, 2024 · These results suggest that TDP-43 M337V may suppress tau exon 10 inclusion and enhance 3R-tau expression via cytoplasmic localization in vivo. Discussion. TDP-43 is the major protein identified in the intracellular ubiquitinated inclusions in ALS and FTLD-U . In the present study, we found that TDP-43 bound intron 9 of TDP-43 pre-mRNA … WebJul 10, 2008 · Approximately equal levels of 3R-tau and 4R-tau are expressed in normal adult human brain, but the 3R-tau/4R-tau ratio is altered in the brains in several tauopathies. ... In the peripheral nervous system, inclusion of exon 4a in the N-terminal half results in the expression of a higher molecular weight (~110 kDa) protein termed big tau [21, 22].
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