Hepatocellularity翻译

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Web1 dec. 2006 · Hepatocellularity numbers were calculated from the ratio between the liver protein concentration and the protein concentration in the corresponding hepatocyte … WebApproximately 60% of marketed compounds are cleared by hepatic CYP-mediated metabolism 1. Hepatocytes contain the full complement of hepatic drug metabolizing …

Scaling factors to relate drug metabolic clearance in hepatic ...

WebFor instance, when hepatocytes are used to predict hepatic drug clearance, the hepatocellularity (number of hepatocytes per gram liver, HPGL) is required as one of … Web1 dec. 2006 · Hepatocellularity numbers were calculated from the ratio between the liver protein concentration and the protein concentration in the corresponding hepatocyte … the crag rat hut

Determination of the hepatocellularity number for human, dog, …

Web1 jul. 2016 · For instance, when hepatocytes are used to predict hepatic drug clearance, the hepatocellularity (number of hepatocytes per gram liver, HPGL) is required as one of … WebNoun [ edit] hepatocellularity ( uncountable ) The condition of being hepatocellular. This page was last edited on 11 March 2024, at 09:48. Text is available under the Creative … Web1 feb. 2014 · Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro (2006) L.T. Lee et al. Removal of unbound sodium dodecyl sulfate (SDS) from proteins in solution by electrophoresis through triton X-100-agarose. the crag st breock

Determination of the hepatocellularity number for human, dog, …

WebMean(geo) hepatocellularity was 163 x 10(6) cells g(-1) liver for Wistar rats (95% CI = 127-199 x 10(6) cells g(-1) liver) and 169 x 10(6) cells g(-1) liver (95% CI = 131-207 x 10(6) … Web1 dec. 2006 · Biotransformation rates measured using cryopreserved trout hepatocytes can be extrapolated to the whole animal to predict metabolism impacts on chemical bioaccumulation, and hepatocytes from male and female juvenile trout may be used interchangeably for in vitro–in vivo metabolism extrapolations. Expand 25 Highly Influenced the crag tasmaniaWeb12 sep. 2003 · Bayliss commented recently on hepatocellularity values, emphasizing the uncertainty of interspecies scaling and indicating that appropriate scaling factors remain to be clarified. Therefore, although the value of 120 × 10 6 cells per gram of liver has often been used in human IVIVE [ 18, 19 ], its accuracy in relation to interindividual differences … the crag westeros

"WebScaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and … " - Hepatocellularity翻译

Hepatocellularity翻译

Scaling factors to relate drug metabolic clearance in hepatic ...

Web1 aug. 1997 · Microsomal protein recovery and hepatocellularity have been determined and investigated as scaling factors for interrelating clearance by hepatic microsomes, freshly isolated hepatocytes and whole liver from untreated (UT) rats and rats treated with either the cytochrome P450 inducer phenobarbital (PB) or dexamethasone (DEX). Web肝细胞癌 (HCC),Hepatocellular Carcinoma (HCC),音标,读音,翻译,英文例句,英语词典 1) Hepatocellular Carcinoma (HCC) 肝细胞癌 (HCC) 2) Hepatocellular carcinoma 肝细胞肝 …

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WebMicrosomal protein per gram of liver (MPPGL) and hepatocellularity number per gram of liver (HPGL) using CYP P450 content method ranged 41–73 mg/gram of liver (mean= 57 … Webhepatocellularity (3.1×109 cells per kilogram body weight, dotted line in Fig. 1)(27). Similar regression analyses for different datasets found that the empirical scaling factors necessary for accurate predictions were 5.2-fold (35) and 5.6-fold larger (45) than hepatocellularity (2.5–3.1×109 cells per

Web28 jan. 2010 · Sandwich-cultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to study hepatobiliary drug transport, species differences in drug transport, transport protein regulation, drug-drug interactions, and hepatotoxicity. Webhepatocellular中文 (简体)翻译：剑桥词典 hepatocellular 在英语-中文（简体）词典中的翻译 hepatocellular adjective medical specialized uk / ˌhep.ə.təʊˈsel.jə.lə r/ us / …

WebHepatocytes / physiology* Male NADPH-Ferrihemoprotein Reductase / metabolism Pharmaceutical Preparations / metabolism* Rats Rats, Wistar WebVALUES OF HUMAN HEPATOCELLULARITY PER GRAM OF LIVER AND ASSOCIATED VARIABILITY FOR USE IN THE PREDICTION OF HUMAN IN VIVO METABOLIC …

WebWilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW, Tucker GT. Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver. Br J Clin Pharmacol. 2003 Oct56(4):433-40. abstract PubMed ID 12968989: Method

WebReported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of liver, generally with no consideration of the extent of their inter-individual variability. We have collated and analysed data from a number of … the cragg vale coinersWeb1 aug. 1997 · Microsomal protein recovery and hepatocellularity have been determined and investigated as scaling factors for interrelating clearance by hepatic microsomes, freshly isolated hepatocytes and whole liver from untreated (UT) rats and rats treated with either the cytochrome P450 inducer phenobarbital (PB) or dexamethasone (DEX). the craggan melnessWebAims: To determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of human liver and their interindividual variability. Methods: Triplicate liver … the craggs blackwaterfootWeb34 Current Drug Metabolism, 2007, Vol. 8, No. 1 Barter et al. weight to give an estimate of whole organ intrinsic clear-ance. The scaling factors for data from liver microsomes, hepatocytes ... the craggs country business park llpWeb1 jan. 2007 · Abstract. Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of liver, generally with no consideration of the extent of their inter-individual variability. We have collated and analysed data from a ... the craggleWeb28 jul. 2016 · The hepatocellularity of the Göttingen minipig was assessed based on the DNA and the protein quantification methods previously used for other species (53,58). For both methodologies, specific amounts of hepatocytes suspension cultures were compared to a specific amount of homogenized liver tissue, assuming that the liver tissue is mainly … the craggs of greenbankWebhepatocellularity - Wiktionary hepatocellularity English [ edit] Etymology [ edit] hepato- +‎ cellularity Noun [ edit] hepatocellularity ( uncountable ) The condition of being hepatocellular This page was last edited on 11 March 2024, at 09:48. Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. the craggs coffee house