WebThe eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been assigned functions in both initiation and elongation. Additionally, it is implicated in transcription, mRNA turnover and nucleocytoplasmic transport. Two eIF5A isoforms are generated from distinct but related genes. The major isoform, eIF5A1, is considered ... WebFeb 5, 2024 · Fig. 1: Heterozygous variants in EIF5A cause a novel craniofacial-neurodevelopmental disorder. a Individuals with de novo heterozygous missense …
Spermidine-mediated hypusination of translation factor EIF5A …
eIF5 is a GTPase-activating protein, which helps the large ribosomal subunit associate with the small subunit. It is required for GTP-hydrolysis by eIF2. eIF5A is the eukaryotic homolog of EF-P. It helps with elongation and also plays a role in termination. EIF5A contains the unusual amino acid hypusine. eIF5B is a GTPase, and is involved in assembly of the full ribosome. It is the functional eukaryoti… WebFeb 23, 2024 · factor eIF5A is necessary for collagen synthesis. First, we used yeast cells carrying temperature-sensitive eIF5A to determine levels of ly expressed heterologousCol1a1 and translation stops at collagenic tripeptide motifs cloned in a dual-luciferase system. Second, we used cultured mouse fibroblasts and depleted active … fewo norderney.de
A translational program that suppresses metabolism to shield
WebNov 13, 2024 · Depletion of eIF5A or Tsc2 leads to metabolic re-initiation and proliferation, but at the expense of incurring substantial DNA damage. We suggest that eIF5A operates as a translatome remodeler ... WebJan 19, 2024 · An early study showed that unmodified eIF5A is unable to catalyze the formation of methionyl-puromycin (Park et al., 1991). Depletion of eIF5A leads to dysregulated translation initiation (Manjunath et al., 2024), elongation/termination (Schuller et al., 2024), and an increase in ribosomal transit times (Henderson and Hershey, 2011). Webn/a Ensembl ENSG00000253626 n/a UniProt Q6IS14 n/a RefSeq (mRNA) NM_001099692 n/a RefSeq (protein) NP_001093162 n/a Location (UCSC) Chr 10: 79.51 – 79.52 Mb n/a PubMed search n/a Wikidata View/Edit Human Eukaryotic translation initiation factor 5A pseudogene 1, also known as EIF5AP1, is a human gene. References ^ a b c GRCh38: … fewo norderney 6 personen