Cisplatin chemistry
WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … WebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin …
Cisplatin chemistry
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WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products.
WebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against … Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ...
WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebSpecifically, the following ionic compounds present in the nutrient medium formed oxidizing agents after electrolysis with platinum electrodes: ammonium sulfate ( (NH 4) 2 SO 4 ); ammonium carbonate ( (NH 4) 2 CO 3 ); ammonium chloride (NH 4 Cl); and other chlorides.
WebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. how many gremlin movies are thereWebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... how 35 years old above treat savingsWebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … how 30% tax on cryptocurrency in indiaWebThe reactions of cisplatin [cis-diamminedichloroplatinum (II), CDDP] with glutathione (GSH) and drug thiols were investigated at 37 degrees C in 100 mM Tris-NO (3), pH approximately 7.4, using a clinically relevant concentration of CDDP (33 micro M), a large excess of GSH (16.5 mM), and [NaCl] of 4.62 mM. how 30 days of yoga can change youWebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, … how many grenades for auto turret rustWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … how many grenades for a stone wall arkWebThis book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how … how360.com