WebMay 13, 2009 · B lymphocyte stimulator (BLyS), a tumor necrosis factor family protein essential for B cell development, was previously shown to be expressed at an elevated … WebOct 29, 2013 · The basis for such confounding outcomes is unclear, but might reflect unwanted effects on B cell selection, or the lack of activity on relevant subsets in some subjects. For example, since BLyS levels are inversely related to mature B cell numbers, serum BLyS levels increase when B cells are ablated (Cambridge et al. 2006; Kreuzaler …
Belimumab - Wikipedia
WebJan 1, 2016 · BlyS and APRIL are mainly produced by innate immune cells such as macrophages, monocytes, and B-cells. BLyS and APRIL contribute to the development of the immune-mediated kidney disease (i.e., SLE) and rejection of the kidney allograft. BLyS and APRIL are new biomarkers that can be used to detect active B-cell-mediated kidney … WebJan 1, 2001 · Mammalian cells transfected with BLyS cDNA secreted active protein,11,13 and overexpression of the protein in the liver of transgenic mice caused effects at distal sites such as the B-cell compartment in the secondary lymphoid organs.15 Using a BLyS-specific ELISA, we have shown that BLyS is released from cells of monocytic origin and … kyg trading
B-cell activating factor - Wikipedia
WebJun 1, 2006 · BLyS, a TNF family member, is crucial for B cell proliferation and differentiation by acting through its three receptors, TACI, BCMA and BAFF-R. The … B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and … See more BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. This cytokine is expressed in See more B-cell activating factor has been shown to interact with TNFRSF13B, TNFSF13, TNFRSF13C, and TNFRSF17. Interaction between BAFF and BAFF-R activates classical … See more As an immunostimulant, BAFF (BLyS, TALL-1) is necessary for maintaining normal immunity. Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency. Excessive level of … See more Human BLyS has been expressed and purified in E. Coli. The BLyS protein in the engineered bacteria can be as much as 50% to the … See more • Nardelli B, Moore PA, Li Y, Hilbert DM (July 2002). "B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases". Leukemia & … See more • B-Cell+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human DTL genome location and See more WebNov 24, 2024 · B-cell activating factor (BAFF, also called B-lymphocyte stimulator, BLyS) is involved in the pathogenesis of SLE and LN. The binding of BAFF to B cells increases their survival and promotes maturation and differentiation toward autoantibody production (Baker et al, Arthr Rheum 2003). BAFF signaling also leads to an increase in anti-apoptotic ... jc motif\u0027s